Publications

Some of our recent Publications.

Mapp Bio Publications

Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.
Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, Deer DJ, Steinkellner H, Bohorov O, Bohorova N, Goodman C, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Crowe JE Jr, Zeitlin L, Geisbert TW.
Sci Transl Med. 2017 Apr 5;9(384).

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses,.
Wec et al., Cell (2017), http://dx.doi.org/10.1016/j.cell.2017.04.037

De Novo MS/MS Sequencing of Native Human Antibodies.
Guthals A, Gan Y, Murray L, Chen Y, Stinson J, Nakamura GR, Lill JR, Sandoval W, Bandeira N.
J Proteome Res. 2016 Oct 25. [Epub ahead of print]

A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection.
PREVAIL II Writing Group.; Multi-National PREVAIL II Study Team.
N Engl J Med. 2016 Oct 13;375(15):1448-1456.

Monoclonal antibody therapy for Junin virus infection.
Zeitlin L, Geisbert JB, Deer DJ, Fenton KA, Bohorov O, Bohorova N, Goodman C, Kim D, Hiatt A, Pauly MH, Velasco J, Whaley KJ, Altmann F, Gruber C, Steinkellner H, Honko AN, Kuehne AI, Aman MJ, Sahandi S, Enterlein S, Zhan X, Enria D, Geisbert TW.
Proc Natl Acad Sci U S A. 2016 Apr 4. pii: 201600996.

Antibody therapeutics for Ebola virus disease.
Zeitlin L, Whaley KJ, Olinger GG, Jacobs M, Gopal R, Qiu X, Kobinger GP.
Curr Opin Virol. 2016 Jan 27;17:45-49. doi: 10.1016/j.coviro.2016.01.006.

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.
Sully EK, Whaley K, Bohorov N, Bohorov O, Goodman C, Kim D, Pauly M, Velasco J, Holtsberg FW, Stavale E, Aman MJ, Tangudu C, Uzal FA, Mantis NJ, Zeitlin L.
Toxicon.2014 Sep 27. pii: S0041-0101(14)00310-9. doi: 10.1016/j.toxicon.2014.09.006. [Epub ahead of print]

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti JB, Fausther-Bovendo H, Wei H, Aviles J, Hiatt E, Johnson A, Morton J, Swope K, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly MH, Velasco J, Pettitt J, Olinger GG, Whaley K, Xu B, Strong JE, Zeitlin L, Kobinger GP.
Nature. 2014 Oct 2;514(7520):47-53. doi: 10.1038/nature13777.

Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana. Garcia JP, Beingesser J, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Roy CJ, Uzal FA.
Toxicon. 2014 Jun 17;88C:93-98.

Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy. Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ, Piedra PA, Gilbert BE, Zeitlin L. Proc Natl Acad Sci U S A. 2014 Apr 7. [Epub ahead of print]

A Chimeric Plantibody Passively Protects Mice against Aerosolized Ricin Challenge. Sully EK, Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ.
Clin Vaccine Immunol. 2014 Feb 26.

Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail. Pettitt J, Zeitlin L, Kim do H, Working C, Johnson JC, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly MH, Whaley KJ, Ingram MF, Zovanyi A, Heinrich M, Piper A, Zelko J, Olinger GG.
Sci Transl Med. 2013 Aug 21;5(199):199ra113.

Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model.
Zeitlin L, Bohorov O, Bohorova N, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Barnard DL, Bates JT, Crowe JE, Piedra PA, Gilbert BE.
MAbs. 2013 Feb 8;5(2).

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.
Olinger GG Jr, Pettitt J, Kim D, Working C, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L, Zeitlin L.
Proc Natl Acad Sci U S A. 2012 Oct 15. [Epub ahead of print]

Emerging Antibody-based Products.
Whaley KJ, Morton J, Hume S, Hiatt E, Bratcher B, Klimyuk V, Hiatt A, Pauly M, Zeitlin L.
Curr Top Microbiol Immunol. 2012 Jul 8.

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.
O’Hara JM, Whaley K, Pauly M, Zeitlin L, Mantis NJ.
Vaccine. 2012 Feb 8;30(7):1239-43.

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant.
Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, Hiatt A, Ngo L, Steinkellner H, Whaley KJ, Olinger GG.
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20690-4.

Rapid high yield production of different glycoforms of Ebola virus monoclonal antibody.
Castilho A, Bohorova N, Grass J, Bohorov O, Zeitlin L, Whaley K, Altmann F, Steinkellner H.
PLoS One. 2011;6(10):e26040.

Emerging antibody products and Nicotiana manufacturing.
Whaley KJ, Hiatt A, Zeitlin L.
Hum Vaccin. 2011 Mar;7(3):349-56.

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant- based transient expression systems.
Pogue GP, Vojdani F, Palmer KE, Hiatt E, Hume S, Phelps J, Long L, Bohorova N, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Garger SJ, White E, Bai Y, Haydon H, Bratcher B.
Plant Biotechnol J. 2010 Jun;8(5):638-54. Review.

Monoclonal antibodies from plants: a new speed record.
Hiatt A, Pauly M.
Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14645-6.

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