Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primatesTherapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates
Larry Zeitlin, Robert W Cross, Courtney Woolsey, Brandon R West, Victoriya Borisevich, Krystle N Agans, Abhishek N Prasad, Daniel J Deer, Lauren Stuart, Maria McCavitt-Malvido, Do H Kim, James Pettitt, James E Crowe Jr, Kevin J Whaley, David Veesler, Anthony Dimitrov, Dafna M Abelson, Thomas W Geisbert, Christopher C Broder
Sci Transl Med 2024 Apr 3;16(741):eadl2055. doi: 10.1126/scitranslmed.adl2055. Epub 2024 Apr 3
Long-term Prophylaxis Against Aerosolized Marburg Virus in Nonhuman Primates With an Afucosylated Monoclonal Antibody
Dafna Abelson, Jennifer Barajas, Lauren Stuart, Do Kim, Arumugapradeep Marimuthu, Chris Hu, Brent Yamamoto, Eric Ailor, Kevin J Whaley, Hong Vu, Krystle N Agans, Viktoriya Borisevich, Daniel J Deer, Natalie S Dobias, Courtney Woolsey, Abhishek N Prasad, Jennifer E Peel, William S Lawrence, Robert W Cross, Thomas W Geisbert, Karla A Fenton, Larry Zeitlin
J infect Dis. 2023 Nov13;228(Supplement_7):S701-S711.doi: 10.1093/infdis/jiad278.
Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody
Larry Zeitlin, Robert W Cross, Joan B Geisbert, Viktoriya Borisevich, Krystle N Agans, Abhishek N Prasad, Sven Enterlein, M Javad Aman, Zachary A Bornholdt, Miles B Brennan, Lioudmila Campbell, Do Kim, Neil Mlakar, Crystal L Moyer, Michael H Pauly, William Shestowsky, Kevin Whaley, Karla A Fenton, Thomas W Geisbert
Proc Natl Acad Sci USA. 2021 Mar 16;118(11):e2023332118. doi: 10.1073/pnas.2023332118.
Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin
Roy CJ, Van Slyke G, Ehrbar D, Bornholdt ZA, Brennan MB, Campbell L, Chen M, Kim D, Mlakar N, Whaley KJ, Froude JW, Torres-Velez FJ, Vitetta E, Didier PJ, Doyle-Meyers L, Zeitlin L, Mantis NJ. NPJ Vaccines. 2020 Feb 13;5:13. doi: 10.1038/s41541-020-0162-0.
Rescue of rhesus macaques from the lethality of aerosolized ricin toxin.
Roy CJ, Ehrbar DJ, Bohorova N, Bohorov O, Kim D, Pauly M, Whaley K, Rong Y, Torres-Velez FJ, Vitetta ES, Didier PJ, Doyle-Meyers L, Zeitlin L, Mantis NJ.
JCI Insight. 2019 Jan 10;4(1). pii: 124771. doi: 10.1172/jci.insight.124771. [Epub ahead of print]
A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.
Bornholdt ZA, Herbert AS, Mire CE, He S, Cross RW, Wec AZ, Abelson DM, Geisbert JB, James RM, Rahim MN, Zhu W, Borisevich V, Banadyga L, Gunn BM, Agans KN, Wirchnianski AS, Goodwin E, Tierney K, Shestowsky WS, Bohorov O, Bohorova N, Velasco J, Ailor E, Kim D, Pauly MH, Whaley KJ, Alter G, Walker LM, Chandran K, Zeitlin L, Qiu X, Geisbert TW, Dye JM
Cell Host Microbe. 2019 Jan 9;25(1)
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.
Wec AZ, Bornholdt ZA, He S, Herbert AS, Goodwin E, Wirchnianski AS, Gunn BM, Zhang Z, Zhu W, Liu G, Abelson DM, Moyer CL, Jangra RK, James RM, Bakken RR, Bohorova N, Bohorov O, Kim DH, Pauly MH, Velasco J, Bortz RH 3rd, Whaley KJ, Goldstein T, Anthony SJ, Alter G, Walker LM, Dye JM, Zeitlin L, Qiu X, Chandran K.
Cell Host Microbe. 2019 Jan 9;25(1)
Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.
Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, Deer DJ, Steinkellner H, Bohorov O, Bohorova N, Goodman C, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Crowe JE Jr, Zeitlin L, Geisbert TW.
Sci Transl Med. 2017 Apr 5;9(384).
De Novo MS/MS Sequencing of Native Human Antibodies.
Guthals A, Gan Y, Murray L, Chen Y, Stinson J, Nakamura GR, Lill JR, Sandoval W, Bandeira N.
J Proteome Res. 2016 Oct 25. [Epub ahead of print]
A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection.
PREVAIL II Writing Group.; Multi-National PREVAIL II Study Team.
N Engl J Med. 2016 Oct 13;375(15):1448-1456.
Monoclonal antibody therapy for Junin virus infection.
Zeitlin L, Geisbert JB, Deer DJ, Fenton KA, Bohorov O, Bohorova N, Goodman C, Kim D, Hiatt A, Pauly MH, Velasco J, Whaley KJ, Altmann F, Gruber C, Steinkellner H, Honko AN, Kuehne AI, Aman MJ, Sahandi S, Enterlein S, Zhan X, Enria D, Geisbert TW.
Proc Natl Acad Sci U S A. 2016 Apr 4. pii: 201600996.
Antibody therapeutics for Ebola virus disease.
Zeitlin L, Whaley KJ, Olinger GG, Jacobs M, Gopal R, Qiu X, Kobinger GP.
Curr Opin Virol. 2016 Jan 27;17:45-49. doi: 10.1016/j.coviro.2016.01.006.
A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.
Sully EK, Whaley K, Bohorov N, Bohorov O, Goodman C, Kim D, Pauly M, Velasco J, Holtsberg FW, Stavale E, Aman MJ, Tangudu C, Uzal FA, Mantis NJ, Zeitlin L.
Toxicon.2014 Sep 27. pii: S0041-0101(14)00310-9. doi: 10.1016/j.toxicon.2014.09.006. [Epub ahead of print]
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti JB, Fausther-Bovendo H, Wei H, Aviles J, Hiatt E, Johnson A, Morton J, Swope K, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly MH, Velasco J, Pettitt J, Olinger GG, Whaley K, Xu B, Strong JE, Zeitlin L, Kobinger GP.
Nature. 2014 Oct 2;514(7520):47-53. doi: 10.1038/nature13777.
Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana.
Garcia JP, Beingesser J, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Roy CJ, Uzal FA.
Toxicon. 2014 Jun 17;88C:93-98.
Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy.
Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ, Piedra PA, Gilbert BE, Zeitlin L. Proc Natl Acad Sci U S A. 2014 Apr 7. [Epub ahead of print]
A Chimeric Plantibody Passively Protects Mice against Aerosolized Ricin Challenge.
Sully EK, Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ.
Clin Vaccine Immunol. 2014 Feb 26.
Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail.
Pettitt J, Zeitlin L, Kim do H, Working C, Johnson JC, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly MH, Whaley KJ, Ingram MF, Zovanyi A, Heinrich M, Piper A, Zelko J, Olinger GG.
Sci Transl Med. 2013 Aug 21;5(199):199ra113.
Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model.
Zeitlin L, Bohorov O, Bohorova N, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Barnard DL, Bates JT, Crowe JE, Piedra PA, Gilbert BE.
MAbs. 2013 Feb 8;5(2).
Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.
Olinger GG Jr, Pettitt J, Kim D, Working C, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L, Zeitlin L.
Proc Natl Acad Sci U S A. 2012 Oct 15. [Epub ahead of print]
Emerging Antibody-based Products.
Whaley KJ, Morton J, Hume S, Hiatt E, Bratcher B, Klimyuk V, Hiatt A, Pauly M, Zeitlin L.
Curr Top Microbiol Immunol. 2012 Jul 8.
Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.
O’Hara JM, Whaley K, Pauly M, Zeitlin L, Mantis NJ.
Vaccine. 2012 Feb 8;30(7):1239-43.
Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant.
Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, Hiatt A, Ngo L, Steinkellner H, Whaley KJ, Olinger GG.
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20690-4.
Rapid high yield production of different glycoforms of Ebola virus monoclonal antibody.
Castilho A, Bohorova N, Grass J, Bohorov O, Zeitlin L, Whaley K, Altmann F, Steinkellner H.
PLoS One. 2011;6(10):e26040.
Emerging antibody products and Nicotiana manufacturing.
Whaley KJ, Hiatt A, Zeitlin L.
Hum Vaccin. 2011 Mar;7(3):349-56.
Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant- based transient expression systems.
Pogue GP, Vojdani F, Palmer KE, Hiatt E, Hume S, Phelps J, Long L, Bohorova N, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Garger SJ, White E, Bai Y, Haydon H, Bratcher B.
Plant Biotechnol J. 2010 Jun;8(5):638-54. Review.
Monoclonal antibodies from plants: a new speed record.
Hiatt A, Pauly M.
Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14645-6.